Muhammad Taqi Misbah Yazdi was born in Yazd, Iran in 1934. In Qum, from 1952 to 1960, he participated in the courses taught by Imam Khomeini, while at the same time, he studied Qur'an exegesis, and the philosophies of Ibn Sina and Mulla Sadra with `Allamah Muhammad Husayn Tabataba'i. He also attended, for approximately fifteen years, Ayatullah Bahjat's fiqh seminars. Ayatullah Misbah's preoccupation with socio-political issues goes back to his active participation in the Islamic uprising against the corrupt Pahlavi regime. When Imam Khomeini was forced into exile, he, accompanied by some other students of Imam including Shahid Beheshti, initiated discussions on Islamic perspectives on social problems such as jihad and the Islamic political system. Along with Ayatullah Dr. Muahmmad Beheshti, Ayatullah Ahmad Jannati, and Ayatullah Ali Quddusi, he was on the board of directors of Madrasah Haqqani, where for about ten years he also taught Qur'anic studies, philosophy, and ethics.
Since 1975 he established, directed, and taught in different academic institutes such as the education department in Dar Rah-i Haqq institute, Baqir al-`ulum Cultural Foundation, Daftar-i Hamkari Hawzah va Danishgah (the office for cooperation between the Hawzah and the university). He is now the director of the Imam Khomeini Education and Research Institute in Qum. He was elected in 1990 to the majlis-i khibrigan-i Rahbari (The Council of Experts in Leaership) from Khuzistan province and was reelected in the next round from Tehran. He is the author of numerous works on Islamic and comparative philosophy, theology, ethics, and Qur'anic exegesis.