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Yes of course. Lady Khadija was believing in Allah (SWT) right from the beginning of her life. That is why she was selected to be the mother of the best lady in whole human kind, Fatima (AS). Not only Lady Khadija but also all her fathers, grandfathers, Mont her and grand mothers were believers in Allah and pious persons. 
Wassalam.

Apart from what was said about the sanctions, I don't think we have any solid historical evidence about this.

It is true that there is a popular biography about her that says that after she got married, her priorities changed and she became uninterested in her business. However, the author did not present his source or reference for this, and so it can't be evaluated. 

Some of these popular biographies are not strongly sourced and come across more as guesswork or the author's idea of how these people should have lived. (If someone finds a source, please add it and I will stand corrected!) Even if there is a source, the source might not be correct, but at least we know where something comes from.

Using purely guesswork... often around mid-life, people change their direction or priorities; similarly, after people succeed in one area of life, they sometimes to go another. One could also imagine that childbirth and having a larger family might have changed her direction in life, especially because (according to reports) she was already extremely wealthy and didn't need to work. However, she was also wealthy enough to have servants and didn't need to spend her time on chores or even things like diapers unless she wanted to. And, it is said that she used her wealth in a lot of charitable causes, so that would have been an incentive to continue. These are just my own guesses however.

Anyway, God knows best.

We do know that when the believers were exiled into the valley of Abu Talib (as) that Khadija (sa) was not able to do trade with others due to the sanctions placed upon the Muslims.

Historical sources list 4 daughters for the Prophet (S). It is not clear whether all of them were his biological daughters, or only one (namely, Fatimah al-Zahra).

If he only had one biological daughter, the other 3 girls who are mentioned in some sources as his daughters would have been girls that he was raising (as adopted daughters), and it would be reasonable to refer to them all generally in this context as "daughters". 

Using a plural also does not preclude daughters in the future, whether they be biological daughters (which didn't happen) or step-daughters (which would have been an open possibility given that he remarried after Hazrat Khadijah). However, if the verse had only said "daughter", and he only had one daughter, it would have been a specific instruction for a specific person and not a general instruction.

Also, the Qur'an occasionally uses a plural form to indicate generality, not multiplicity. For instance, the verse of mubahilah instructs the Prophet to take "our selves" and "our women" (in the plural) to the meeting for mubahilah, but he only brought one person as his "self" (Imam 'Ali) and one person as "his women" (Fatimah al-Zahra'). 

Lastly, a prophet can be considered a father of his people (as in "I and 'Ali are the fathers of this ummah"), and so referring, in general, to the girls of the community as his "daughters" would not be unreasonable, particularly since the verse also addresses the "believing women", although admittedly this is not the interpretation that first comes to mind. 

Historical matters can be complicated. It can be difficult to know the exact details of what happened over a thousand years ago. One has to have faith that Allah has preserved what is necessary for us to know, and in this case the emphasis is on the spirit of the ayah rather than the specifics of lineage.